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In fact, the terms 'multifactorial' and 'polygenic' are used as synonyms and these terms are commonly used to describe the architecture of disease causing genetic component. [2] Multifactorial diseases are often found gathered in families yet, they do not show any distinct pattern of inheritance.
If multifactorial inheritance is indeed the case, then the chance of the patient contracting the disease is reduced only if cousins and more distant relatives have the disease. [13] While multifactorially-inherited diseases tend to run in families, inheritance will not follow the same pattern as a simple monohybrid or dihybrid cross. [10]
Genetic disorders may also be complex, multifactorial, or polygenic, meaning they are likely associated with the effects of multiple genes in combination with lifestyles and environmental factors. Multifactorial disorders include heart disease and diabetes. Although complex disorders often cluster in families, they do not have a clear-cut ...
A polygene is a member of a group of non-epistatic genes that interact additively to influence a phenotypic trait, thus contributing to multiple-gene inheritance (polygenic inheritance, multigenic inheritance, quantitative inheritance [1]), a type of non-Mendelian inheritance, as opposed to single-gene inheritance, which is the core notion of Mendelian inheritance.
Studies to date have shown that when numerous families are studied, simple modes of inheritance are not statistically supported. The majority of studies analyzing for the mode of inheritance have concluded that a multifactorial threshold mode is most likely. [2]
Multifactorial (having many factors) can refer to: The multifactorial in mathematics. Multifactorial inheritance , a pattern of predisposition for a disease process.
An example of the codominant inheritance of some of the four blood groups. Mendelian traits in humans are human traits that are substantially influenced by Mendelian inheritance. Most – if not all – Mendelian traits are also influenced by other genes, the environment, immune responses, and chance.
Endometriosis is a heritable condition influenced by both genetic and environmental factors, [53] a genetic disorder of polygenic/multifactorial inheritance [54] acquired via affected genes from either a person's father or mother.