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Due to its feminising side effects and risk of infertility it is not often used by men. [ 32 ] [ 33 ] It can also cause low blood pressure , high blood potassium , and abnormal heart rhythms . Also, women who are pregnant or trying to become pregnant generally cannot use the medication as it is a teratogen , and can cause ambiguous genitalia in ...
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Adverse effects, like therapeutic effects of drugs, are a function of dosage or drug levels at the target organs, so they may be avoided or decreased by means of careful and precise pharmacokinetics, the change of drug levels in the organism in function of time after administration. Adverse effects may also be caused by drug interaction. This ...
These side effects may occur in as many as 90% of men treated with bicalutamide monotherapy, [29] but gynecomastia is generally reported to occur in 70 to 80% of patients. [30] In the EPC trial, at a median follow-up of 7.4 years, breast pain and gynecomastia respectively occurred in 73.6% and 68.8% of men treated with 150 mg/day bicalutamide ...
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