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Telmisartan, sold under the brand name Micardis among others, is a medication used to treat high blood pressure and heart failure. [3] [6] It is a reasonable initial treatment for high blood pressure. [6] It is taken by mouth. [6] Common side effects include upper respiratory tract infections, diarrhea, and back pain. [6]
Use during pregnancy may harm the baby. [2] Telmisartan works by blocking the effects of angiotensin II while amlodipine works by decreasing calcium ion entry into smooth muscle and heart muscle. [2] The combination was approved for medical use in the United States in 2009. [2]
Telmisartan has a carboxylic acid at the 2-position of the biphenyl-methyl group and is more potent than the tetrazole analogue. [ 1 ] It has been reported that imidazoles that have hydroxymethyl and carboxy groups at the 4- and 5 position, possessed potent antagonistic activity, caused by the hydrogen bonding and hydrophilicity of the ...
It may be used if telmisartan by itself is not sufficient. [5] It is taken by mouth. [5] Common side effects include dizziness, upper respiratory tract infections, nausea, diarrhea, and tiredness. [2] Severe side effects may include kidney problems, electrolyte problems, and allergic reactions. [2] Use during pregnancy may harm the baby. [2]
[8] Candesartan is used experimentally in preventive treatment of migraine. [9] [10] Lisinopril has been found less often effective than candesartan at preventing migraine. [11] The angiotensin II receptor blockers have differing potencies in relation to blood pressure control, with statistically differing effects at the maximal doses. [12]
Cilnidipine is approved for use in Japan, China, India, Nepal, and Korea for hypertension. It is a calcium antagonist accompanied with L -type and N -type calcium channel blocking functions. Unlike other calcium antagonists, cilnidipine can act on the N -type calcium channel in addition to acting on the L -type calcium channel.
About 14% of an oral dosage is converted to this metabolite, which is long-acting (6 to 8 hours) and a noncompetitive antagonist at the AT 1 receptor, contributing to the pharmacological effects of losartan. EXP3174 is 10–40 times more potent in blocking AT 1 receptors than losartan. In addition, the binding to the target enzyme is pH ...
Amlodipine/olmesartan, sold under the brand name Azor, among others is a fixed-dose combination medication used to treat high blood pressure. [5] It contains amlodipine, as the besilate, a dihydropyridine calcium channel blocker, and olmesartan medoxomil, an angiotensin II receptor blocker.
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