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CA19-9 can be elevated in many types of gastrointestinal cancer, such as colorectal cancer, esophageal cancer and hepatocellular carcinoma. [1] Apart from cancer, elevated levels may occur in pancreatitis, cirrhosis, [1] and diseases of the bile ducts. [1] [3] It can also be elevated in people with obstruction of the bile ducts. [3]
Levels of the tumor markers carbohydrate antigen 19-9 (CA 19–9), carcinoembryonic antigen (CEA) and CA 125 are abnormally high in the bloodstreams of patients with intrahepatic cholangiocarcinoma and Klatskin tumor. The serum CA 19–9 in particular may be very high. [10]
Each assay may give different results of the clinical value of the p53 mutations as a prognostic factor. [ 6 ] Interlaboratory proficiency testing for tumor marker tests, and for clinical tests more generally, is routine in Europe and an emerging field [ 7 ] in the United States.
CA19-9 (carbohydrate antigen 19.9) is a tumor marker that is frequently elevated in pancreatic cancer. However, it lacks sensitivity and specificity, not least because 5% of people lack the Lewis (a) antigen and cannot produce CA19-9. It has a sensitivity of 80% and specificity of 73% in detecting pancreatic adenocarcinoma, and is used for ...
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The results of this trial demonstrated a stable disease for 10/18 patients ( 56%) and had no immunogenic response. M5A-DOTA was coupled with 225-Ac , which is an alpa emitter, and an in vivo study was performed where cytokine therapy was combined with a-therapy. [30] The result of the study revealed the benefit of combining these two treamtents.
Researchers utilized a nude mouse model with orthotopic gastric cancer cell xenografts to verify the in vitro results. The scientists discovered that gastric cancer tissues demonstrated high levels of CAMSAP2. The results positively correlated with tumor markers carcinoembryonic antigen and CA19-9.
230099 Ensembl ENSG00000107159 ENSMUSG00000028463 UniProt Q16790 Q8VHB5 RefSeq (mRNA) NM_001216 NM_139305 RefSeq (protein) NP_001207 NP_647466 Location (UCSC) Chr 9: 35.67 – 35.68 Mb Chr 4: 43.51 – 43.51 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Carbonic anhydrase IX (CA9/CA IX) is an enzyme that in humans is encoded by the CA9 gene. It is one of the 14 carbonic anhydrase ...