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Treatment should take into account the cause and severity of the condition. [6] Treatment is done by vitamin B 12 supplementation, either by mouth or by injection. [3] Initially in high daily doses, followed by less frequent lower doses, as the condition improves. [3] If a reversible cause is found, that cause should be corrected if possible. [11]
Methylcobalamin is also offered as a dietary supplement. [12] There is no advantage to the use of adenosylcobalamin or methylcobalamin forms for the treatment of vitamin B 12 deficiency. [20] [21] [4] Hydroxocobalamin can be injected intramuscularly to treat vitamin B 12 deficiency. It can also be injected intravenously for the purpose of ...
Cerefolin is a prescription medication made by Pamlab that contains 5.635 mg of folate as L-methylfolate, 1 mg of vitamin B 12 as methylcobalamin, 50 mg of vitamin B 2 as riboflavin, and 5 mg of vitamin B 6 as pyridoxine. It is approved by the U.S. Food and Drug Administration for the treatment or prevention of vitamin deficiencies. [1]
Methylcobalamin (mecobalamin, MeCbl, or MeB 12) is a cobalamin, a form of vitamin B 12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. [1] Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. [2]
Deficiency in pregnant women can lead to birth defects, particularly neural tube defects such as spina bifida and anencephaly. Vitamin B 12: Cobalamins: Vitamin B 12 deficiency results in a macrocytic anemia, elevated methylmalonic acid and homocysteine, peripheral neuropathy, sense loss
Cyanocobalamin is a form of vitamin B 12 used to treat and prevent vitamin B 12 deficiency except in the presence of cyanide toxicity. [7] [8] [2] The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer.
As a supplement it is used to treat vitamin B12 deficiency including pernicious anemia. [1] [2] Other uses include treatment for cyanide poisoning, Leber's optic atrophy, and toxic amblyopia. [3] [4] It is given by injection into a muscle or vein, [2] by pill or sublingually. Side effects are generally few. [2]
Neuropathy, ataxia, and retinitis pigmentosa, also known as NARP syndrome, is a rare disease with mitochondrial inheritance that causes a variety of signs and symptoms chiefly affecting the nervous system [1] Beginning in childhood or early adulthood, most people with NARP experience numbness, tingling, or pain in the arms and legs (sensory neuropathy); muscle weakness; and problems with ...
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