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An internal ribosome entry site, abbreviated IRES, is an RNA element that allows for translation initiation in a cap-independent manner, as part of the greater process of protein synthesis. Initiation of eukaryotic translation nearly always occurs at and is dependent on the 5' cap of mRNA molecules, where the translation initiation complex ...
This family represents the internal ribosome entry site (IRES) of the hepatitis A virus. [1] HAV IRES is a 450 nucleotide long sequence [2] located in the 735 nt long 5’ UTR (untranslated region) of Hepatitis A viral RNA genome. [1] IRES elements allow cap and end-independent translation of mRNA in the host cell.
In contrast, translation of hepatitis C virus (HCV) mRNA is initiated by a different mechanism from the usual 5' cap-binding model. [1] This alternate mechanism relies on the direct binding of the 40S ribosomal subunit by the internal ribosome entry site (IRES) in the 5' UTR of HCV RNA.
The c-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of C-myc and allows cap-independent translation. The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death. c-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the ...
In molecular biology, the ODC internal ribosome entry site (IRES) is an RNA element present in the 5′ UTR of the mRNA encoding ornithine decarboxylase.It has been suggested that this IRES allows cap-independent translation of ornithine decarboxylase at the G2/M phase of the cell cycle, [1] however there is some doubt about this. [2]
The Tobamovirus internal ribosome entry site (IRES) is an element that allows cap and end-independent translation of mRNA in the host cell. [1] The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor, eIF4F.
In molecular biology, the Ure2 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of Ure2.It allows 5' cap- and eIF4E-independent translation of an N-terminally truncated form of Ure2.
The BiP internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of BiP protein and allows cap-independent translation. BiP protein expression has been found to be significantly enhanced by the heat shock response due to internal ribosome entry site (IRES)-dependent translation.