Search results
Results from the WOW.Com Content Network
Calcium tends to have a slightly lower affinity for PMCA pumps than for SERCA pumps. [9] It is thought that the PMCA pump has 10 segments that cross the plasma membrane, with both C and N termini on the inside of the cell. [2] At the C terminus, there is a long "tail" of between 70 and 200 amino acids in length. [2]
Valproic acid has a black box warning for hepatotoxicity, pancreatitis, and fetal abnormalities. [4] There is evidence that valproic acid may cause premature growth plate ossification in children and adolescents, resulting in decreased height. [40] [41] [42] Valproic acid can also cause mydriasis, a dilation of the pupils. [43]
Rendered image of the Ca 2+ pump. Plasma membrane Ca 2+ ATPase (PMCA) is a transport protein in the plasma membrane of cells that serves to remove calcium (Ca 2+) from the cell. It is vital for regulating the amount of Ca 2+ within cells. [3] In fact, the PMCA is involved in removing Ca 2+ from all eukaryotic cells. [4]
Leukopenia (low white blood cell count) Neutropenia (low neutrophil count) Pure red cell aplasia; Agranulocytosis; Extrapyramidal syndrome (including parkinsonism, may be reversible) Brain problems due to high ammonia levels; Low body temperature; Hypersensitivity reactions including multi-organ hypersensitivity syndrome; Eosinophilic pleural ...
The use of the affected pumps may also cause serious adverse health consequences, including hypertension, lack of blood flow and death, according to the health regulator. The recall is a ...
Acid–base and blood gases are among the few blood constituents that exhibit substantial difference between arterial and venous values. [6] Still, pH, bicarbonate and base excess show a high level of inter-method reliability between arterial and venous tests, so arterial and venous values are roughly equivalent for these.
Diagnosis should generally include either a calculation of corrected calcium or direct measurement of ionized calcium level and be confirmed after a week. [1] This is because either high or low serum albumin levels does not show the true levels of ionised calcium. [15]
The plasma total calcium concentration is in the range of 2.2–2.6 mmol/L (9–10.5 mg/dL), and the normal ionized calcium is 1.3–1.5 mmol/L (4.5–5.6 mg/dL). [4] The amount of total calcium in the blood varies with the level of plasma albumin, the most abundant protein in plasma, and therefore the main carrier of protein-bound calcium in the blood.