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HPLC has many applications in both laboratory and clinical science. It is a common technique used in pharmaceutical development, as it is a dependable way to obtain and ensure product purity. [59] While HPLC can produce extremely high quality (pure) products, it is not always the primary method used in the production of bulk drug materials. [60]
The first clinical prediction model reporting guidelines were published in 2015 (Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD)), and have since been updated. [10] Predictive modelling has been used to estimate surgery duration.
The charged aerosol detector (CAD) is a detector used in conjunction with high-performance liquid chromatography (HPLC) and ultra high-performance liquid chromatography (UHPLC) to measure the amount of chemicals in a sample by creating charged aerosol particles which are detected using an electrometer.
The spot capacity (analogous to peak capacity in HPLC) can be increased by developing the plate with two different solvents, using two-dimensional chromatography. [8] The procedure begins with development of a sample loaded plate with first solvent. After removing it, the plate is rotated 90° and developed with a second solvent.
The best model relating log K and log P was found to be one in which the total molar charge of a compound at a given pH is included as a variable. This model proved to give fairly accurate predictions of log P, R > 0.9. [18] Other studies have been performed which develop predictive QRAR models for tricyclic antidepressants [17] and ...
The successful prediction of a stock's future price could yield significant profit. The efficient market hypothesis suggests that stock prices reflect all currently available information and any price changes that are not based on newly revealed information thus are inherently unpredictable. Others disagree and those with this viewpoint possess ...
Price Sensitivity Meter (van Westendorp) The Price Sensitivity Meter (PSM) is a market technique for determining consumer price preferences. It was introduced in 1976 by Dutch economist Peter van Westendorp. The technique has been used by a wide variety of researchers in the market research industry. It historically has been promoted by many ...
A second limitation is the inability to model strategies that would affect historic prices. Finally, backtesting, like other modeling, is limited by potential overfitting . That is, it is often possible to find a strategy that would have worked well in the past, but will not work well in the future. [ 1 ]