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The enzyme sterol esterase (EC 3.1.1.13) catalyzes the reaction a sterol ester + H 2 O ⇌ {\displaystyle \rightleftharpoons } a sterol + a fatty acid This enzyme belongs to the family of hydrolases , specifically those acting on carboxylic ester bonds.
57552 320024 Ensembl ENSG00000144959 ENSMUSG00000027698 UniProt Q6PIU2 Q8BLF1 RefSeq (mRNA) NM_020792 NM_001146276 NM_001146277 NM_001146278 NM_178772 RefSeq (protein) NP_001139748 NP_001139749 NP_001139750 NP_065843 NP_848887 Location (UCSC) Chr 3: 172.63 – 172.71 Mb Chr 3: 27.24 – 27.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Neutral cholesterol ester hydrolase 1 (NCEH ...
Cholesterol is a sterol, a steroid-like lipid made by animals, including humans.The human body makes one-eighth to one-fourth teaspoons of pure cholesterol daily. A cholesterol level of 5.5 millimoles per litre or below is recommended for an adult.
Cholesterol is the principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. [3] [4]Cholesterol is biosynthesized by all animal cells [citation needed] and is an essential structural and signaling component of animal cell membranes.
Increased levels of cholesteryl ester have been found in certain parts of the brain of people with Huntington's disease. Higher concentrations of cholesteryl ester have been found in the caudate and putamen , but not the cerebellum , of people with Huntington disease compared with levels in controls. [ 4 ]
Sterol esters are a heterogeneous group of chemical compounds. They are created when the hydroxyl group of a sterol and a fatty acid undergo an esterification reaction. They can be found in trace amounts in every cell type but are highly enriched in foam cells and are common components of human skin oil .
In biochemistry, an esterase is a class of enzyme that splits esters into an acid and an alcohol in a chemical reaction with water called hydrolysis (and as such, it is a type of hydrolase). A wide range of different esterases exist that differ in their substrate specificity, their protein structure , and their biological function.
Sterol esterase; Phospholipase; Several nucleases that degrade nucleic acids, like DNAase and RNAase; Pancreatic amylase that breaks down starch and glycogen which are alpha-linked glucose polymers. Humans lack the cellulases to digest the carbohydrate cellulose which is a beta-linked glucose polymer.