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The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in the first place.
One study has shown the allergic reaction rate to be about 3.0% over 359 courses of therapy. [11] Of the allergic reactions, skin rashes, eosinophilia and drug fever were the most common, while serious reactions were less common. Sulfamethoxazole is contraindicated in people with a known hypersensitivity to trimethoprim or sulfonamides. [9]
Wilkes calculated the height of Mount Rainier using the triangulation method to a height of 12,330 feet, approximately 2000 feet less than the actual height of the mountain. [4] The Wilkes expedition made the first successful navigation over the Naches Pass just north of Mount Rainier, which had been seen as a potential route for overland wagon ...
Mount Rainier [a] (/ r eɪ ˈ n ɪər / ray-NEER), also known as Tahoma, is a large active stratovolcano in the Cascade Range of the Pacific Northwest in the United States. The mountain is located in Mount Rainier National Park about 59 miles (95 km) south-southeast of Seattle. [9]
Mount Rainier National Park is a national park of the United States located in southeast Pierce County and northeast Lewis County in Washington state. [3] The park was established on March 2, 1899, as the fourth national park in the United States, preserving 236,381 acres (369.3 sq mi; 956.6 km 2) [1] including all of Mount Rainier, a 14,410-foot (4,390 m) stratovolcano.
The term over-the-counter (OTC) refers to a medication that can be purchased without a medical prescription. [3] In contrast, prescription drugs require a prescription from a doctor or other health care professional and should only be used by the prescribed individual. [4]
Stevens climbed Mount Rainier a second time in 1905 on a trip organized by The Mazamas, an Oregon mountaineering club. [7] Stevens established the Cloverfields Dairy Farm in Olympia, Washington in 1916. Now on the National Historic Register, the former farm is the site of the present Olympia High School. [2]
Over time, methods for testing the sensitivity of bacteria to antibiotics have developed and changed. [25] Alexander Fleming in the 1920s developed the first method of susceptibility testing. The "gutter method" that he developed was a diffusion method, involving an antibiotic that was diffused through a gutter made of agar. [25]