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Carboplatin, sold under the brand name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer. [3] This includes ovarian cancer , lung cancer , head and neck cancer , brain cancer , and neuroblastoma . [ 3 ]
This mechanism leads to specific patterns of damage in DNA, which can kill cancer cells but can also increase the risk of secondary tumors developing. [6] Platinum-based antineoplastic agents are sometimes described as "alkylating-like" due to similar effects as alkylating antineoplastic agents, although they do not have an alkyl group. [7]
The death of the fetus can occur from the immune system's reaction to the fetus through the examination of its mechanism in animal studies. [5] Dostarlimab is a human immunoglobulin G (IgG4), which could permeate through the placental barrier. [5] This may risk harm to the developing fetus as the drug may be passed on from the mother. [5]
Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid and haematological malignancies. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g., small cell lung cancer, squamous cell carcinoma of the head and neck and ovarian cancer), lymphomas, bladder cancer, cervical cancer, [9] and germ cell tumors.
Pemetrexed is also recommended in combination with carboplatin and pembrolizumab for the first-line treatment of advanced non-small cell lung cancer. [12] [13] However, the relative efficacy or toxicity of pemetrexed-cisplatin versus pemetrexed-carboplatin has not been established beyond what is generally thought about cisplatin or carboplatin doublet drug therapy.
Feister, Alan J. Medical defense against mustard gas: toxic mechanisms and pharmacological implications (1991). online; Fitzgerald, Gerard J. "Chemical warfare and medical response during World War I." American journal of public health 98.4 (2008): 611-625. online. Freemantle M (2012). Gas! GAS! Quick, boys! How Chemistry Changed the First ...
Emesis is a defense mechanism controlled by the area postrema of the medulla oblongata.There are various sources of input to the vomiting center. Receptors on the floor of the fourth ventricle of the brain represent the chemoreceptor trigger zone.
Topotecan is a semi-synthetic derivative of camptothecin.Camptothecin is a natural product extracted from the bark of the tree Camptotheca acuminata.Topoisomerase-I is a nuclear enzyme that relieves torsional strain in DNA by opening single strand breaks. [20]
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