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Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must first get into the cell before viral replication can occur. Through the generation of abundant copies of its genome and packaging these copies, the virus continues infecting new hosts. Replication between viruses is ...
To enter the cells, proteins on the surface of the virus interact with proteins of the cell. Attachment, or adsorption, occurs between the viral particle and the host cell membrane. A hole forms in the cell membrane, then the virus particle or its genetic contents are released into the host cell, where replication of the viral genome may commence.
A typical virus replication cycle Some bacteriophages inject their genomes into bacterial cells (not to scale) Viral populations do not grow through cell division, because they are acellular. Instead, they use the machinery and metabolism of a host cell to produce multiple copies of themselves, and they assemble in the cell. [74]
A viral infection does not always cause disease. A viral infection simply involves viral replication in the host, but disease is the damage caused by viral multiplication. [5] An individual who has a viral infection but does not display disease symptoms is known as a carrier. [17] Mechanisms by which viruses cause damage and disease to host cells
A viroplasm, sometimes called "virus factory" or "virus inclusion", [1] is an inclusion body in a cell where viral replication and assembly occurs. They may be thought of as viral factories in the cell. There are many viroplasms in one infected cell, where they appear dense to electron microscopy. Very little is understood about the mechanism ...
The virion host shutoff protein (VHS or UL41) is very important to viral replication. [42] This enzyme shuts off protein synthesis in the host, degrades host mRNA, helps in viral replication, and regulates gene expression of viral proteins. The viral genome immediately travels to the nucleus, but the VHS protein remains in the cytoplasm. [43] [44]
Newly synthesized viral polymerase subunits and NP proteins are imported to the nucleus to further increase the rate of viral replication and form RNPs. [30] HA, NA, and M2 proteins are trafficked with the aid of M1 and NEP proteins [32] to the cell membrane through the Golgi apparatus [30] and inserted into the cell's membrane. Viral non ...
(A) The replication of virophages is supposed to occur entirely in the virus factory of its giant virus host, depending on the giant virus expression/replication complex. (B) The concept of satellite virus implicates that the virus initiates the expression and replication of its genome in the nucleus using the host cell machinery and then goes ...