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In the United States, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. [5] [6]In the European Union, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in people with type 2 diabetes; in combination with a sulfonylurea as an adjunct to diet and exercise "in people ...
It is also available in the fixed-dose combination medication sitagliptin/metformin (Janumet, Janumet XR). [8] Common side effects include headaches, swelling of the legs, and upper respiratory tract infections. [8] Serious side effects may include angioedema, low blood sugar, kidney problems, pancreatitis, and joint pain. [8]
DPP-4 inhibitors combined with metformin include a sitagliptin/metformin combination (Janumet), [203] [204] a saxagliptin/metformin combination (Kombiglyze XR, Komboglyze), [205] [206] and an alogliptin/metformin combination (Kazano, Vipdomet). [207] [208] Linagliptin combined with metformin hydrochloride is sold under the brand name Jentadueto.
The list price on Merck's diabetes drug Janumet increased 293% since it hit the market in 2007, the largest increase among all 25 drugs, according to the report.
Other serious side effects may include medullary thyroid cancer, angioedema, pancreatitis, and kidney injury. [7] Use in pregnancy and breastfeeding is of unclear safety. [ 9 ] Exenatide is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) also known as incretin mimetics . [ 7 ]
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A large study published in Nature Medicine reviewed the effects of GLP-1 drugs like Ozempic and Mounjaro on 175 different health outcomes. The findings show benefits for brain and heart health ...
Sitagliptin: Using male and female rats, a two-year carcinogenicity study was carried out with doses of 50, 150, and 500 mg/kg/day. The 500 mg/kg dose has exposure limits of 60 times what would be seen in the highest dose in humans.