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Cystic hygromas that develop in the third trimester, after 30 weeks' gestation, or in the postnatal period are usually not associated with chromosome abnormalities. A chance exists of recurrence after surgical removal of the cystic hygroma. The chance depends on the extent of the cystic hygroma and whether its wall was completely removed. [10]
Manouvrier-Hanu et al. (1996) described the prenatal diagnosis of Fryns syndrome by ultrasonographic detection of diaphragmatic hernia and cystic hygroma. [9] The diagnosis was confirmed after termination of the pregnancy. The fetus also had 2 erupted incisors; natal teeth had not been mentioned in other cases of Fryns syndrome.
Cystic lymphangioma that emerges during the first two trimesters of pregnancy is associated with genetic disorders such as Noonan syndrome and trisomies 13, 18, and 21. Chromosomal aneuploidy such as Turner syndrome or Down syndrome [8] were found in 40% of patients with cystic hygroma. [9]
Usually, no treatment is used if the pyogenic granuloma occurs during pregnancy, since the lesion may heal spontaneously. Recurrent bleeding in either oral or nasal lesions may necessitate excision and cauterization sooner, however. If aesthetics are a concern, then treatment may be prioritized.
In the first trimester, cystic hygroma and thickened nuchal translucency may be observed. Macrosomia, macrocephaly, enlarged kidneys, macroglossia, cardiac abnormalities, and visceromegaly may become evident by the second and third trimesters. [1] [3] Polyhydramnios is frequently observed. [2]
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Cystic hygroma; Dandy–Walker malformation; Diaphragmatic hernia; Diastrophic dysplasia; Double outlet right ventricle; Duodenal atresia; Ebstein's anomaly; Ectopia cordis; Encephalocele; Endocardial cushion defect; Esophageal atresia; Exstrophy of the bladder; Fetal alcohol syndrome; First arch syndrome; Focal femoral hypoplasia ...