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Topical diclofenac sodium gel is a nonsteroidal anti-inflammatory drug that is thought to work in the treatment of AK through its inhibition of the arachidonic acid pathway, thereby limiting the production of prostaglandins which are thought to be involved in the development of UVB-induced skin cancers. [40]
Diclofenac is believed to work by decreasing the production of prostaglandins, like other drugs in this class. [17] In 2022, it was the 51st most commonly prescribed medication in the United States, with more than 12 million prescriptions. [18] [19] It is available as its acid or in two salts, as either diclofenac sodium or potassium. [15]
The symptoms of DRESS syndrome usually begin 2 to 6 weeks but uncommonly up to 8–16 weeks after exposure to an offending drug. Symptoms generally include fever, an often itchy rash which may be morbilliform or consist mainly of macules or plaques, facial edema (i.e. swelling, which is a hallmark of the disease), enlarged and sometimes painful lymph nodes, and other symptoms due to ...
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Sausage-like swelling in the fingers or toes, known as dactylitis, occurs in about 40% of PsA cases. [5] [7] PsA may cause shoulder pain, most commonly felt in the front of the shoulder or the upper part of the arm. It is usually felt when moving the arm and may only be noticed in certain movements.
These differential effects are due to the different roles and tissue localisations of each COX isoenzyme. [11] By inhibiting physiological COX activity, NSAIDs may cause deleterious effects on kidney function, [12] and, perhaps as a result of water and sodium retention and decreases in renal blood flow, may lead to heart problems. [13]
Less-common side effects can include excess air or gas in your stomach, burping, heartburn, indigestion, fast heartbeat, low blood sugar, low energy and fatigue, or even gallstones, Dr. Comite says.
The main symptoms include several kinds of skin rash along with muscle weakness in both upper arms or thighs. [8] Although dermatomyositis is closely related to polymyositis and is sometimes assumed to be a complication of that disease, most patients with dermatomyositis develop skin symptoms before any muscle involvement.