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Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
Medical calculators arose because modern medicine makes frequent use of scores and indices that put physicians' memory and calculation skills to the test. [2] The advent of personal computers, the Internet and Web, and more recently personal digital assistants (PDAs) have formed an environment conducive to their development, spread and use.
Retroactive research conducted at the time the term "Dosage Index" first became common knowledge revealed that at that time no horse having a Dosage Index of higher than 4.00 had won the Kentucky Derby since at least 1929 (a year chosen because by then the number of available of chefs-de-race on which to base the figures was thought to have ...
The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...
In physiology and medicine, the body surface area (BSA) is the measured or calculated surface area of a human body.For many clinical purposes, BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass.
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Animal models are used to learn more about a disease, its diagnosis and its treatment, with animal models predicting human toxicity in up to 71% of cases. [1] The human equivalent dose (HED) or human equivalent concentration (HEC) is the quantity of a chemical that, when administered to humans, produces an effect equal to that produced in test animals by a smaller dose. [2]