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The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration. LD 50 figures are frequently used as a general indicator of a substance's acute toxicity. A lower LD 50 is indicative of higher toxicity. The term LD 50 is generally attributed to John William Trevan. [2]
Type III collagen is synthesized by cells as a pre-procollagen. [6] The signal peptide is cleaved off producing a procollagen molecule. Three identical type III procollagen chains come together at the carboxy-terminal ends, and the structure is stabilized by the formation of disulphide bonds. Each individual chain folds into a left-handed helix ...
First, a three-dimensional stranded structure is assembled, mostly composed of the amino acids glycine and proline. This is the collagen precursor procollagen. Then, procollagen is modified by the addition of hydroxyl groups to the amino acids proline and lysine.
A fatal dose for humans can be as low as 1 to 1.5 mg, and other source also states that oral LD 50 is 3.16 mg per kg body weight. [4] Due to lack of studies on the toxicokinetics of bongkrek acid, there are no specific treatments or antidotes for bongkrek acid. The commonly used protocol to treat bongkrek acid poisoning is to remove the toxins ...
[99] [100] If catabolism of alcohol goes all the way to completion, then there is a very exothermic event yielding some 1325 kJ/mol of energy. If the reaction stops part way through the metabolic pathways, which happens because acetic acid is excreted in the urine after drinking, then not nearly as much energy can be derived from alcohol ...
ADAMTS2 is responsible for processing several types of procollagen proteins. Procollagens are the precursors of collagens, the proteins that add strength and support to many body tissues. Specifically, this enzyme clips a short chain of amino acids off one end of the procollagen. This clipping step is necessary for collagen molecules to ...
The 3 substrates of this enzyme are procollagen L-proline, 2-oxoglutarate, and O 2, whereas its 3 products are procollagen trans-3-hydroxy-L-proline, succinate, and CO 2. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen ...
Death from ethanol consumption is possible when blood alcohol levels reach 0.4%. A blood level of 0.5% or more is commonly fatal. The oral median lethal dose (LD 50) of ethanol in rats is 5,628 mg/kg. Directly translated to human beings, this would mean that if a person who weighs 70 kg (150 lb) drank a 500 mL (17 US fl oz) glass of pure ...