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Maleimide-mediated methodologies are among the most used in bioconjugation. [5] [6] Due to fast reactions and high selectivity towards cysteine residues in proteins, a large variety of maleimide heterobifunctional reagents are used for the preparation of targeted therapeutics, assemblies for studying proteins in their biological context, protein-based microarrays, or proteins immobilisation. [7]
The MEROPS online database for peptidases and their inhibitors: NEM [permanent dead link ]; The bifunctional analogues such as p-NN′-phenylenebismaleimide can be used as cross-linking reagent for cystine residues.
In enzymology, a maleimide hydrolase (EC 3.5.2.16) is an enzyme that catalyzes the chemical reaction maleimide + H 2 O ⇌ {\displaystyle \rightleftharpoons } maleamic acid Thus, the two substrates of this enzyme are maleimide and H 2 O , whereas its product is maleamic acid .
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TCEP is often used as a reducing agent to break disulfide bonds within and between proteins as a preparatory step for gel electrophoresis.. Compared to the other two most common agents used for this purpose (dithiothreitol and β-mercaptoethanol), TCEP has the advantages of being odorless, a more powerful reducing agent, an irreversible reducing agent (in the sense that TCEP does not ...
Electronically-available alternative data, such as social media activity, bill payments, mobile telephone bills and metadata, rental payments, and electronic transaction data, could be used to score these individuals and enter millions in low-income countries into a more modern credit ratings system.
Before data mining algorithms can be used, a target data set must be assembled. As data mining can only uncover patterns actually present in the data, the target data set must be large enough to contain these patterns while remaining concise enough to be mined within an acceptable time limit. A common source for data is a data mart or data ...
The siamang (/ ˈ s iː ə m æ ŋ /, also UK: / ˈ s aɪ ə-/; [5] [6] Symphalangus syndactylus) is an endangered arboreal, black-furred gibbon native to the forests of Indonesia, Malaysia, and Thailand.