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Klotho is an antagonist of the Wnt signaling pathway, and chronic Wnt stimulation can lead to stem cell depletion and aging. [46] Klotho inhibition of Wnt signaling can inhibit cancer. [36] The anti-aging effects of klotho are also a consequence of increased resistance to inflammation and oxidative stress. [19]
[12] [13] [14] It has since been shown that Klotho can act to protect against Parkinson's and multiple sclerosis. [7] The mechanisms that underpin Klotho's enhancement of cognitive ability are still unknown. [7] Alongside working on mouse models, in 2019, Dubal was the first to show that Klotho may protect people from Alzheimer's disease.
BioViva was founded in 2015. [2] The CEO, Elizabeth Parrish, started the company by becoming the first person in human history to take gene therapies associated with lengthening lifespans in model organism, [3] she appeared at WIRED Health 2017 in London to discuss BioViva's testing of gene therapies targeting hallmarks of the ageing process.
Higher blood levels of Klotho in later life correlate with longevity, while lower levels are associated with premature aging and susceptibility to develop certain neurological disorders. Although results in animal studies may not always directly correspond to outcomes in human clinical studies, we were very encouraged by these findings.
Both Dr. Chaudhry and Holdorf recommend PCA Skin's anti-aging serums to target several of the most common signs of mature skin: dryness, sensitivity, wrinkles, fine lines, age spots and thinning skin.
Contact Information: You can contact the Senior Center between 8 am and 5 pm Monday through Friday (at 850-891-4000) for more information regarding the Tallahassee Senior Center activities, or ...
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