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Selenium is a cofactor for the three thyroid hormone deiodinases, helping activate and then deactivate various thyroid hormones and their metabolites. Isolated selenium deficiency is now being investigated for its role in the induction of autoimmune reactions in the thyroid gland in Hashimoto's disease . [ 162 ]
Chosen for its selenium content and high solubility, sodium selenate is a common ingredient in over-the-counter vitamin supplements. Selenium is a trace essential element. Sodium selenate and selenite are also common in premix animal feed. Neither compound has demonstrated a difference in the amount of selenium absorbed.
Iodotyrosine deiodinase contributes to breakdown of thyroid hormones. It releases iodine, for renewed use, from iodinated tyrosines resulting from catabolism of iodothyronines. Iodotyrosine deiodinase employs a flavin mononucleotide cofactor and belongs to the NADH oxidase/flavin reductase superfamily. [2]
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