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  2. Aripiprazole - Wikipedia

    en.wikipedia.org/wiki/Aripiprazole

    This mixture of agonist actions at D2-dopamine receptors is consistent with the hypothesis that aripiprazole has "functionally selective" actions. [92] The "functional-selectivity" hypothesis proposes that a mixture of agonist/partial agonist/antagonist actions are likely.

  3. List of adverse effects of aripiprazole - Wikipedia

    en.wikipedia.org/wiki/List_of_adverse_effects_of...

    Neuroleptic malignant syndrome (Combination of fever, muscle stiffness, faster breathing, sweating, reduced consciousness, and sudden change in blood pressure and heart rate)

  4. Hope for Parkinson’s disease symptoms is found in ... - AOL

    www.aol.com/finance/hope-parkinson-disease...

    Tavapadon aims to treat Parkinson’s motor symptoms by mimicking dopamine in a once-a-day oral dose. ... as a first-in-class D1/D5 partial agonist [medication targeting specific dopamine ...

  5. Dopamine agonist - Wikipedia

    en.wikipedia.org/wiki/Dopamine_agonist

    Dopamine agonists are mainly used to treat Parkinson's disease, but also hyperprolactinemia and restless legs syndrome. [15] The side effects are predominantly collected from studies of Parkinson's disease, where dopamine agonists are commonly used as a first-line treatment with levodopa. [16]

  6. Management of Parkinson's disease - Wikipedia

    en.wikipedia.org/wiki/Management_of_Parkinson's...

    Treatment in the initial state aims to attain an optimal tradeoff between good management of symptoms and side effects resulting from enhancement of dopaminergic function. The start of L-DOPA treatment may be delayed by using other medications such as MAO-B inhibitors and dopamine agonists, in the hope of delaying the onset of dyskinesias. [3]

  7. Antipsychotic - Wikipedia

    en.wikipedia.org/wiki/Antipsychotic

    Third-generation antipsychotics were introduced in the 2000s and offer partial agonism, rather than blockade, of dopamine receptors. [14] Neuroleptic , originating from Ancient Greek : νεῦρον ( neuron ) and λαμβάνω ( take hold of )—thus meaning "which takes the nerve" —refers to both common neurological effects and side effects.

  8. Dopamine antagonist - Wikipedia

    en.wikipedia.org/wiki/Dopamine_antagonist

    Its side effects include weight gain but there is lower risk for orthostatic hypotension and hyperprolactinemia. Aripiprazole binds D 2 as a partial agonist but antagonizes D 3. [20] In addition, aripiprazole treats schizophrenia, bipolar disorder (mania), [21] depression, [1] and tic disorders [20] Clozapine

  9. Dopamine receptor D2 - Wikipedia

    en.wikipedia.org/wiki/Dopamine_receptor_D2

    Dopamine receptor D 2, also known as D 2 R, is a protein that, in humans, is encoded by the DRD2 gene.After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon H. Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now known as the dopamine D 2 receptor. [5]

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