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The "vaptan" drugs act by directly blocking the action of vasopressin at its receptors (V 1A, V 1B and V 2).These receptors have a variety of functions, with the V 1A and V 2 receptors are expressed peripherally and involved in the modulation of blood pressure and kidney function respectively, while the V 1A and V 1B receptors are expressed in the central nervous system.
Nephrogenic DI may be treated by addressing the underlying cause or by the use of a thiazide, aspirin or ibuprofen. [1] The number of new cases of diabetes insipidus each year is 3 in 100,000. [4] Central DI usually starts between the ages of 10 and 20 and occurs in males and females equally. [2] Nephrogenic DI can begin at any age. [3]
The Mercury News headquarters in downtown San Jose. The Mercury News is the largest tenant in the Towers @ 2nd high-rise office complex in downtown San Jose. [64] Business functions occupy the seventh floor of 4 North Second Street, while news staff and executives occupy the eighth floor, for a total of 33,186 square feet (3,083.1 m 2). [4]
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Bay Area News Group (BANG) is the largest publisher of daily and weekly newspapers in the San Francisco Bay Area, including its flagship The Mercury News. A subsidiary of the Denver -based MediaNews Group , [ 2 ] its corporate headquarters is in San Jose, California , and publication offices in San Jose . [ 3 ]
The San Jose Jazz Society was started by Metro jazz writer Sammy Cohen and headquartered in Metro's office. The outgrowth was the annual San Jose Jazz Festival. [22] During the 1990s, Metro purchased community newspapers from companies such as the Tribune Company and established Silicon Valley Community Newspapers, which it sold in 2001.
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