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Magnesium affects the Hypothalamic–pituitary–adrenal axis in the brain, which controls the stress response system and therefore, anxiety and depression. [5] Tentative data indicate that oral magnesium supplementation may be effective for treating mild to moderate adult depression. [6] [7]
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Etifoxine, sold under the trade name Stresam among others, is a nonbenzodiazepine anxiolytic agent, primarily indicated for short-term management of adjustment disorder, specifically instances of situational depression accompanied by anxiety, such as stress-induced anxiety. [2] [6] Administration is by mouth. [7]
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