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Technetium (99m Tc) sestamibi is a lipophilic cation which, when injected intravenously into a patient, distributes in the myocardium proportionally to the myocardial blood flow. Single photon emission computed tomography imaging of the heart is performed using a gamma camera to detect the gamma rays emitted by the technetium-99m as it decays.
Technetium-99m (99m Tc) is a metastable nuclear isomer of technetium-99 (itself an isotope of technetium), symbolized as 99m Tc, that is used in tens of millions of medical diagnostic procedures annually, making it the most commonly used medical radioisotope in the world.
Technetium (99m Tc) tetrofosmin is a drug used in nuclear medicine cardiac imaging.It is sold under the brand name Myoview (GE Healthcare).The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and which are referred to as tetrofosmin.
By the late 1980s, two different compounds containing technetium-99m were introduced: teboroxime [10] and sestamibi. The utilization of Tc-99m would allow higher doses (up to 1,100 MBq or 30 mCi) due to the shorter physical (6 hours) half life of Tc-99m.
FDA Approves Navidea's Lymphoseek ® (technetium Tc 99m tilmanocept) Injection for Use in Lymphatic Mapping The first receptor-targeted radiopharmaceutical approved for lymphatic mapping in breast ...
The patient is placed under a gamma camera, which detects the low-level 140 keV gamma radiation being given off by Technetium-99m (99m Tc). As the gamma camera images are acquired, the patient's heart beat is used to 'gate' the acquisition. The final result is a series of images of the heart (usually sixteen), one at each stage of the cardiac ...
A cardiac specific radiopharmaceutical is administered, e.g., 99m Tc-tetrofosmin (Myoview, GE healthcare), 99m Tc-sestamibi (Cardiolite, Bristol-Myers Squibb) or Thallium-201 chloride. Following this, the heart rate is raised to induce myocardial stress, either by exercise on a treadmill or pharmacologically with adenosine , dobutamine , or ...
The most common isotope used in diagnostic scans is Technetium-99m, used in approximately 85% of all nuclear medicine diagnostic scans worldwide. It is used for diagnoses involving a large range of body parts and diseases such as cancers and neurological problems. [1]