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BSH Guideline: Evidence-based guidelines developed following a professional literature search and a review of the evidence by the writing group. BSH Good Practice Paper: Used to recommend good practice in areas where there is a less robust evidence base but for which a degree of consensus or uniformity is likely to be beneficial to patient care.
Patients received either two or, in a few instances, one BNCT treatment using BPA (400 mg/kg), administered i.v. over 2 hours, followed by neutron irradiation. Of 29 evaluated patients, there were 13 complete and 9 partial remissions, with an overall response rate of 76%.
A BNCT therapeutic candidate must selectively accumulate in target tissue without significant uptake in normal tissue. If selectivity is low and boron accumulates in both, irradiation with thermal neutrons will cause significant damage to healthy tissue; if boron accumulates in neither, the treatment will be ineffective.
Prevention includes gamma irradiation of the lymphocyte-containing blood components such as red blood cells, platelets and granulocytes. Irradiated blood components should be issued in the following situations: [7] Intrauterine transfusions; Prematurity, low birthweight, or erythroblastosis fetalis in newborns; Congenital immunodeficiencies
Blood irradiation therapy is an alternative medical procedure in which the blood is exposed to low-level light (often laser light) for therapeutic reasons. [1] The practice was originally developed in the United States, [ 1 ] but most recent research on it has been conducted in Germany (by UV lamps ) and in Russia (in all variants).
Total body irradiation (TBI) is a form of radiotherapy used primarily as part of the preparative regimen for haematopoietic stem cell (or bone marrow) transplantation. As the name implies, TBI involves irradiation of the entire body, though in modern practice the lungs are often partially shielded to lower the risk of radiation-induced lung ...
White blood cells – due to the effective inactivation of white blood cells in donated blood products, riboflavin and UV light treatment may be used as an alternative to gamma-irradiation for the prevention of transfusion-associated graft-versus-host disease (TA-GVHD), [7] a serious blood transfusion-related complication.
The treatment has also been studied in people with aplastic anemia (a condition in which a person's bone marrow does not produce enough blood cells) and chronic granulomatous disease (a disorder in which a person has a normal number of neutrophils, but they do not function correctly).