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Women should speak to their doctor or healthcare professional before starting or stopping any medications while pregnant. [1] Drugs taken in pregnancy including over-the counter-medications, prescription medications, nutritional supplements, recreational drugs, and illicit drugs may cause harm to the mother or the unborn child.
Most ASMs may require higher doses during pregnancy due to changes in drug clearance. However, women with epilepsy should reduce these increased doses in the first few weeks after giving birth to prevent potential toxicity. Symptoms of toxicity include dizziness, vomiting, and blurry/double vision.
Eperisone has not been established to be safe for use by pregnant women; therefore the drug should not be used in pregnant women, or women who may be pregnant, if the expected therapeutic benefits will outweigh the possible risks associated with treatment. The manufacturers of Myonal recommend the drug not be used during lactation (breast ...
Use of anticonvulsant medications should be carefully monitored during use in pregnancy. [94] For example, since the first trimester is the most susceptible period for fetal development, planning a routine antiepileptic drug dose that is safer for the first trimester could be beneficial to prevent pregnancy complications. [95]
People taking topiramate should be aware of the following risks: Avoid activities requiring mental alertness and coordination until drug effects are realized. Topiramate may impair heat regulation, [36] especially in children. Use caution with activities leading to an increased core temperature, such as strenuous exercise, exposure to extreme ...
The mechanism by which ethosuximide affects neuronal excitability includes block of T-type calcium channels, and may include effects of the drug on other classes of ion channel. The primary finding that ethosuximide is a T-type calcium channel blocker gained widespread support, but initial attempts to replicate the finding were inconsistent.
It is pregnancy category D in Australia, meaning that it may cause harm when taken during pregnancy. [6] [12] If used during breastfeeding it may result in drowsiness in the baby. [13] Phenobarbital works by increasing the activity of the inhibitory neurotransmitter GABA. [6] Phenobarbital was discovered in 1912 and is the oldest still commonly ...
[30] [11] However, food has been found to substantially delay the absorption of pregabalin and to significantly reduce peak levels without affecting the bioavailability of the drug; T max values for pregabalin of 0.6 hours in a fasted state and 3.2 hours in a fed state (5-fold difference), and the C max is reduced by 25–31% in a fed versus ...