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Asparaginase is an enzyme that is used as a medication and in food manufacturing. [6] [7] As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL). [6] It is given by injection into a vein, or muscle. [6] A pegylated version is also available. [8] In food manufacturing it is used to ...
Non-small cell lung cancer, oesophageal cancer, uterine cervical cancer, head and neck cancer and urothelial cancer: Nephrotoxicity, myelosuppression and nausea and vomiting (30-90%). Oxaliplatin: IV: Reacts with DNA, inducing apoptosis, non-cell cycle specific. Colorectal cancer, oesophageal cancer and gastric cancer
However, the opposite effect is visible in cases of asparaginase resistant cancers. [3] In these resistant cancers, the effect of blood asparagine depletion through L-asparaginase instead leads to significant asparagine synthetase overexpression to compensate, effectively nullifying the effect of the chemotherapy drug. [3]
66514 Ensembl ENSG00000162174 ENSMUSG00000024654 UniProt Q7L266 Q8C0M9 RefSeq (mRNA) NM_001083926 NM_025080 NM_025610 RefSeq (protein) NP_001077395 NP_079356 NP_079886 Location (UCSC) Chr 11: 62.34 – 62.39 Mb Chr 19: 9.09 – 9.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse L-asparaginase is an enzyme that in humans is encoded by the ASRGL1 gene. Function The ASRGL1 protein ...
In a 2019 survey cited in the advisory, just 45% of Americans said they were aware alcohol was a risk factor for cancer, compared to 91% for radiation exposure, 89% for tobacco use, 81% for ...
Medicinal fungi are fungi that contain metabolites or can be induced to produce metabolites through biotechnology to develop prescription drugs.Compounds successfully developed into drugs or under research include antibiotics, anti-cancer drugs, cholesterol and ergosterol synthesis inhibitors, psychotropic drugs, immunosuppressants and fungicides.
Whole-person specialty care, a model where a comprehensive care team works together to coordinate personalized and individualized treatment, is offering renewed hope for patients.
Costco membership also gives shoppers access to the club's travel deals. The company revealed its largest booking in the last year was a 150-day cruise around the world.. CFO Gary Millerchip said ...