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Asparaginase is an enzyme that is used as a medication and in food manufacturing. [6] [7] As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL). [6] It is given by injection into a vein, or muscle. [6] A pegylated version is also available. [8] In food manufacturing it is used to ...
However, the opposite effect is visible in cases of asparaginase resistant cancers. [3] In these resistant cancers, the effect of blood asparagine depletion through L-asparaginase instead leads to significant asparagine synthetase overexpression to compensate, effectively nullifying the effect of the chemotherapy drug. [3]
Calaspargase pegol is an engineered protein consisting of the E. coli-derived enzyme L-asparaginase II conjugated with succinimidyl carbonate monomethoxypolyethylene glycol . [6] The L-asparaginase portion hydrolyzes L-asparagine to L-aspartic acid depriving the tumor cell of the L-asparagine it needs for survival. [ 6 ]
Non-small cell lung cancer, oesophageal cancer, uterine cervical cancer, head and neck cancer and urothelial cancer: Nephrotoxicity, myelosuppression and nausea and vomiting (30-90%). Oxaliplatin: IV: Reacts with DNA, inducing apoptosis, non-cell cycle specific. Colorectal cancer, oesophageal cancer and gastric cancer
This approach, of course, is the case for diagnosing cancer, and early detection can help save lives. ... If you don’t have a primary care provider, you should be able to get these tests done at ...
When my husband was diagnosed with cancer, I was shell-shocked. My routines were upended at the same time I became his caregiver. I reached out to family and other caregivers for support. People ...
Cancer patients in west Norfolk are benefiting from a new surgical robot. The £1m machine called Versius allows surgeons to perform long, complex procedures more comfortably.. It has been bought ...
66514 Ensembl ENSG00000162174 ENSMUSG00000024654 UniProt Q7L266 Q8C0M9 RefSeq (mRNA) NM_001083926 NM_025080 NM_025610 RefSeq (protein) NP_001077395 NP_079356 NP_079886 Location (UCSC) Chr 11: 62.34 – 62.39 Mb Chr 19: 9.09 – 9.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse L-asparaginase is an enzyme that in humans is encoded by the ASRGL1 gene. Function The ASRGL1 protein ...