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Rosavin (also known as rosin, rosavin, and rosarin) are a family of cinnamyl mono- and diglycosides that are key ingredients of Rhodiola rosea L., (R. rosea). R. rosea is an important medicinal plant commonly used throughout Europe, Asia, and North America, that has been recognized as a botanical adaptogen by the European Medicines Agency. [1]
It has been studied, along with rosavin, as one of the potential compounds responsible for the putative antidepressant and anxiolytic actions of this plant. [2] [3] Salidroside may be more active than rosavin, [4] even though many commercially marketed Rhodiola rosea extracts are standardized for rosavin content rather than salidroside.
Perfumi M, Mattioli L. Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytother Res 2007 Jan;21(1):37-43. Pooja, Bawa AS, Khanum F. Anti-inflammatory activity of Rhodiola rosea--"a second-generation adaptogen". Phytother Res. 2009 Aug;23(8):1099-1102.
Rhodiola rosea is from 5 to 40 centimetres (2.0 to 15.7 in) tall, fleshy, and has several stems growing from a short, scaly rootstock. Flowers have 4 sepals and 4 petals, yellow to greenish yellow in color sometimes tipped with red, about 1 to 3.5 millimetres (0.039 to 0.138 in) long, and blooming in summer.
Type A: augmented pharmacological effects, which are dose-dependent and predictable [5]; Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g., bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g., nausea from digoxin), and they are therefore predictable.
An extract (essence) is a substance made by extracting a part of a raw material, often by using a solvent such as ethanol, oil or water. Extracts may be sold as tinctures or absolutes or dried and powdered.
From February 2011 to December 2012, if you bought shares in companies when Evan G. Greenberg joined the board, and sold them when he left, you would have a 12.3 percent return on your investment, compared to a 6.4 percent return from the S&P 500.
Many synthetic and semisynthetic drugs are structural modifications of the alkaloids, which were designed to enhance or change the primary effect of the drug and reduce unwanted side-effects. [208] For example, naloxone , an opioid receptor antagonist , is a derivative of thebaine that is present in opium .
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