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Bioactive glasses have been synthesized through methods such as conventional melting, quenching, the sol–gel process, flame synthesis, and microwave irradiation.The synthesis of bioglass has been reviewed by various groups, with sol-gel synthesis being one of the most frequently used methods for producing bioglass composites, particularly for tissue engineering applications.
material science; nanotechnology, [61] bioconjugation, for example, azidocoumarin, and; biomaterials [62] In combination with combinatorial chemistry, high-throughput screening, and building chemical libraries, click chemistry has hastened new drug discoveries by making each reaction in a multistep synthesis fast, efficient, and predictable.
Bioactive metallic glass is a subset of bioactive glass, wherein the bulk material is composed of a metal-glass substrate and is coated with bioactive glass in order to make the material bioactive. The reasoning behind the introduction of the metallic base is to create a less brittle, stronger material that will be permanently implanted within ...
Enzymes catalyze chemical reactions involving the substrate(s). In the case of a single substrate, the substrate bonds with the enzyme active site, and an enzyme-substrate complex is formed. The substrate is transformed into one or more products, which are then released from the active site. The active site is then free to accept another ...
Four general approaches have been used to achieve this objective: 1) use of the bioactive ceramic as a coating on a metal or ceramic substrate 2)strengthening of the ceramic, such as via crystallization of glass 3) use of fracture mechanics as a design approach and 4) reinforcing of the ceramic with a second phase.
A bioactive compound is a compound that has an effect on a living organism, tissue or cell, usually demonstrated by basic research in vitro or in vivo in the laboratory. While dietary nutrients are essential to life, bioactive compounds have not been proved to be essential – as the body can function without them – or because their actions are obscured by nutrients fulfilling the function.
In biology, a substrate is the surface on which an organism (such as a plant, fungus, or animal) lives.A substrate can include biotic or abiotic materials and animals. For example, encrusting algae that lives on a rock (its substrate) can be itself a substrate for an animal that lives on top of the algae.
SBF was first introduced by Kokubo et al. in order to evaluate the changes on a surface of a bioactive glass ceramic. [2] Later, cell culture media (such as DMEM, MEM, α-MEM, etc.), in combination with some methodologies adopted in cell culture , were proposed as an alternative to conventional SBF in assessing the bioactivity of materials.