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The researchers discovered that people who had high fluctuations in their cholesterol levels had a 60 percent higher risk of developing dementia and a 23 percent greater risk of cognitive decline.
People with the highest fluctuations in total cholesterol levels had a 60% higher likelihood of dementia, and a 23% increase in cognitive decline, compared with those with the most stable ...
The direct relationship between cholesterol and dementia is still unclear, though elevated levels of specifically LDL cholesterol are considered a risk factor for dementia, says Peter Gliebus, M.D ...
The cholesterol is produced in the astrocytes and shipped to neurons where it activates amyloid production through a process called substrate presentation. The process required apoE. Cholesterol's regulation of Tau production is less well understood, but knocking out the cholesterol synthesis enzyme SREBP2 decreased Tau phosphorylation.
Retrogenesis is a medical hypothesis that just as the fetus goes through a process of neurodevelopment beginning with neurulation and ending with myelination, the brains of people with Alzheimer's disease go through a reverse neurodegeneration process starting with demyelination and death of axons (white matter) and ending with the death of ...
There has yet to be a distinct link between the two because it is hard to determine exactly how each aspect of aging effects the memory and aging process. However, it is known that the brain shrinks with age due to the expansion of ventricles causing there to be little room in the head. Unfortunately, it is hard to provide a solid link between ...
A new study found the biggest risk factors and predictors at 60 for dementia at 80. Neurologists weigh in on the research and share ways to prevent dementia.
Most cases of early-onset Alzheimer's share the same traits as the "late-onset" form and are not caused by known genetic mutations. Little is understood about how it starts. Nonfamilial early-onset AD can develop in people who are in their 30s or 40s, but this is extremely rare, [ 3 ] and mostly people in their 50s or early 60s are affected.