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The researchers discovered that people who had high fluctuations in their cholesterol levels had a 60 percent higher risk of developing dementia and a 23 percent greater risk of cognitive decline.
The cholesterol is produced in the astrocytes and shipped to neurons where it activates amyloid production through a process called substrate presentation. The process required apoE. Cholesterol's regulation of Tau production is less well understood, but knocking out the cholesterol synthesis enzyme SREBP2 decreased Tau phosphorylation.
People with the highest fluctuations in total cholesterol levels had a 60% higher likelihood of dementia, and a 23% increase in cognitive decline, compared with those with the most stable ...
The direct relationship between cholesterol and dementia is still unclear, though elevated levels of specifically LDL cholesterol are considered a risk factor for dementia, says Peter Gliebus, M.D ...
Retrogenesis is a medical hypothesis that just as the fetus goes through a process of neurodevelopment beginning with neurulation and ending with myelination, the brains of people with Alzheimer's disease go through a reverse neurodegeneration process starting with demyelination and death of axons (white matter) and ending with the death of ...
Binswanger's disease, also known as subcortical leukoencephalopathy and subcortical arteriosclerotic encephalopathy, [1] is a form of small-vessel vascular dementia caused by damage to the white brain matter. [2]
While there are different forms of dementia, Vascular dementia as it would sound is associated with vascular cautions. [14] This form of dementia is not a slow deterioration but rather a sudden and unexpected change due to heart attack or stroke [15] significantly reducing blood to the brain. [14]
1. Alzheimer's disease: know the symptoms. Alzheimer's disease "is an illness of the brain that occurs primarily in older people where brain cells start to die," Devi says.