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The cells were first noted by Henle in 1837 when studying the lining of the small intestine, seen to be mucus producing by Leydig in 1857 (who was examining the epidermis of fish), and were given their name by Schulze in 1867, [24] [25] Schulze chose the descriptive name "goblet" because of the shape of the cell, rather than a functional name ...
These are known as non-ciliated columnar epithelium. Non-ciliated simple columnar epithelium is made up of glandular goblet cells which secrete mucin to form mucus. [1] The rest of the cell is made up of cytoplasm with membrane bound secretory granules which secrete the mucin, and are found towards the apical surface of the cell. [1]
Absorptive cell: Epithelium/intestinal glands: Digestion and absorption of nutrients in chyme Goblet cell: Epithelium/intestinal glands: Secretion of mucus Paneth cell: Intestinal glands: Secretion of the bactericidal enzyme lysozyme; phagocytosis G cells: Intestinal glands of duodenum: Secretion of the hormone intestinal gastrin: I cells
Goblet cells secrete the mucus layer which protects the epithelium from the luminal contents. Enteroendocrine cells secrete various gastrointestinal hormones including secretin, pancreozymin, enteroglucagon among others. Subsets of sensory intestinal epithelial cells synapse with nerves, [9] and are known as neuropod cells. [10]
Mucus forms a layer (or layers, in the case of the colon) that separates the bulk of the luminal contents from the intestinal epithelium.The mucus consists of a highly glycosylated hydrated gel formed by mucin molecules that are secreted by goblet cells.
During each mitosis, one of the two daughter cells remains in the crypt as a stem cell, while the other differentiates and migrates up the side of the crypt and eventually into the villus. These stem cells can differentiate into either an absorptive (enterocytes) or secretory (Goblet cells, Paneth cells, enteroendocrine cells) lineages. [3]
Diagram showing bicarbonate secretion to the stomach lumen. The mucus produced by these cells is extremely important, as it prevents the stomach from digesting itself. [5] Parietal cells produce potent hydrochloric acid, which damages cells. Gastric chief cells produce pepsinogen, which is activated by the acid to form pepsin. Pepsin is a ...
The GI tract is composed of the alimentary canal, that runs from the mouth to the anus, as well as the associated glands, chemicals, hormones, and enzymes that assist in digestion. The major processes that occur in the GI tract are: motility, secretion, regulation, digestion and circulation.