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The main efficacy measurement was the time to death from cardiovascular causes or need to be hospitalized for heart failure. [33] Of the individuals who received empagliflozin for an average of about two years, 14% died from cardiovascular causes or were hospitalized for heart failure, compared to 17% of the participants who received the ...
Heart failure with preserved ejection fraction (HFpEF) is a form of heart failure in which the ejection fraction – the percentage of the volume of blood ejected from the left ventricle with each heartbeat divided by the volume of blood when the left ventricle is maximally filled – is normal, defined as greater than 50%; [1] this may be measured by echocardiography or cardiac catheterization.
Packer M, Butler J et al. "Empagliflozin and Major Renal Outcomes in Heart Failure." N Engl J Med 2021. Butler J et al. "Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials." Lancet 2024.
A heart which cannot pump sufficient blood to meet the body's requirements (i.e., heart failure) will often, but not invariably, have a reduced ventricular ejection fraction. [6] In heart failure, the difference between heart failure with a reduced ejection fraction, and heart failure with a preserved ejection fraction, is significant, because ...
Left-sided heart failure may be present with a reduced ejection fraction or with a preserved ejection fraction. [10] Heart failure is not the same as cardiac arrest, in which blood flow stops completely due to the failure of the heart to pump. [12] [13] Diagnosis is based on symptoms, physical findings, and echocardiography. [6]
Praliciguat was tried in a phase II trial for heart failure with preserved ejection fraction [6] Olinciguat was developed for sickle cell disease but its development was discontinued in 2020. [ 7 ]
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The main pathophysiology of heart failure is a reduction in the efficiency of the heart muscle, through damage or overloading. As such, it can be caused by a wide number of conditions, including myocardial infarction (in which the heart muscle is starved of oxygen and dies), hypertension (which increases the force of contraction needed to pump blood) and cardiac amyloidosis (in which misfolded ...
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