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The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
Use in pregnancy and breastfeeding is of unclear safety. [5] It works by blocking H + /K +-ATPase in the parietal cells of the stomach. [3] Dexlansoprazole was approved for medical use in the United States in 2009. [3] In Canada in 2016, it was the most expensive Proton-pump inhibitor (PPI) available. [4]
Proton-pump inhibitors have largely superseded the H 2-receptor antagonists, a group of medications with similar effects but a different mode of action, and heavy use of antacids. [3] A potassium-competitive acid blocker (PCAB) revaprazan was marketed in Korea as an alternative to a PPI.
PPIs, which include heartburn drugs such as Prilosec, Nexium and Prevacid, are one of the best-selling classes of drugs in the world. Should you stop taking your heartburn medicine? Skip to main ...
Lansoprazole is used for treatment of: [3] Ulcers of the stomach and duodenum, and NSAID-induced ulcers; Helicobacter pylori infection, alongside antibiotics (adjunctive treatment), treatment to kill H. pylori causing ulcers or other problems involves using two other drugs besides lansoprazole known as "triple therapy", and involves taking twice daily for 10 or 14 days lansoprazole ...
Use in pregnancy appears to be safe. [5] Pantoprazole is a proton pump inhibitor that decreases gastric acid secretion. [5] It works by inactivating (H+/K+)-ATPase function in the stomach. [9] [5] The study of pantoprazole began in 1985, and it came into medical use in Germany in 1994. [10] It is available as a generic medication.
A study of more than 11,000 adults suggests an association between migraine attacks or severe headaches and proton pump inhibitors (PPIs) like esomeprazole (Nexium) and omeprazole (Prilosec ...
Effectiveness is similar to other proton pump inhibitors (PPIs). [8] It is taken by mouth. [6] Common side effects include constipation, feeling weak, and throat inflammation. [6] Serious side effects may include osteoporosis, low blood magnesium, Clostridioides difficile infection, and pneumonia. [6] Use in pregnancy and breastfeeding is of ...
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