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Muscimol (also known as agarin or pantherine) is one of the principal psychoactive constituents of Amanita muscaria and related species of mushroom. Muscimol is a potent and selective orthosteric agonist for the GABA A receptor [3] and displays sedative-hypnotic, depressant and hallucinogenic [citation needed] psychoactivity.
Ibotenic acid or (S)-2-amino-2-(3-hydroxyisoxazol-5-yl)acetic acid, also referred to as ibotenate, is a chemical compound and psychoactive drug which occurs naturally in Amanita muscaria and related species of mushrooms typically found in the temperate and boreal regions of the northern hemisphere.
As with other Amanita muscaria, the inzengae variety contains ibotenic acid, and muscimol, two psychoactive constituents which can cause effects such as hallucinations, synaesthesia, euphoria, dysphoria and retrograde amnesia. The effects of muscimol and ibotenic acid most closely resemble that of any GABAergic compound, but with a dissociative ...
Ibotenic acid is mostly broken down into the body to muscimol, but what remains of the ibotenic acid is believed [2] to cause the majority of dysphoric effects of consuming A. muscaria mushrooms. Ibotenic acid is also a scientifically important neurotoxin used in lab research as a brain-lesioning agent in mice. [3] [4]
Amanita muscaria, commonly known as the fly agaric or fly amanita, [5] is a basidiomycete of the genus Amanita. It is a large white- gilled , white-spotted, and usually red mushroom. Despite its easily distinguishable features, A. muscaria is a fungus with several known variations, or subspecies .
The fly amanita is considered by many to be dangerous to eat. Columnist Rick Marsi shares the curious story of a nature walk where they were seen. There's more to this curious orange mushroom than ...
Experts say the Amanita muscaria, a red and white psychoactive mushroom, earned its place in holiday decor through some surprising origins. (Photo: Getty Creative) (bbbrrn via Getty Images)
Trace concentrations of muscarine are also found in Amanita muscaria, though the pharmacologically more relevant compound from this mushroom is the Z-drug-like alkaloid muscimol. A. muscaria fruitbodies contain a variable dose of muscarine, usually around 0.0003% fresh weight. This is very low and toxicity symptoms occur very rarely.