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These repeats show homology to members of INTERPRO and INTERPRO indicating that they are likely to form a beta-propeller. The fourteen repeats are likely to form two propellers; it is not clear if these structures are likely to recruit other proteins or interact with DNA.
WD40 domain-containing proteins have 4 to 16 repeating units, all of which are thought to form a circularised beta-propeller structure (see figure to the right). [3] [4] The WD40 domain is composed of several repeats, a variable region of around 20 residues at the beginning followed by a more common repeated set of residues.
A logical spreadsheet is a spreadsheet in which formulas take the form of logical constraints rather than function definitions.. In traditional spreadsheet systems, such as Excel, cells are partitioned into "directly specified" cells and "computed" cells and the formulas used to specify the values of computed cells are "functional", i.e. for every combination of values of the directly ...
Examples of proteins that contain armadillo repeats include β-catenin, Sarm1 , [4] α-importin, [5] plakoglobin, [6] adenomatous polyposis coli (APC), [7] and many others. The term armadillo derives from the historical name of the β-catenin gene in the fruitfly Drosophila where the armadillo repeat was first discovered.
InterPro is a database of protein families, protein domains and functional sites in which identifiable features found in known proteins can be applied to new protein sequences [2] in order to functionally characterise them.
In biochemistry and medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin α IIb β 3) is an integrin complex found on platelets.It is a transmembrane receptor for fibrinogen [1] and von Willebrand factor, and aids platelet activation.
Domains of unknown function (DUFs) represent a growing fraction of the Pfam database. The families are so named because they have been found to be conserved across species, but perform an unknown role. Each newly added DUF is named in order of addition. Names of these entries are updated as their functions are identified.
InterPro Transforming growth factor beta (TGFβ) receptors are single pass serine/threonine kinase receptors that belong to TGFβ receptor family . They exist in several different isoforms that can be homo - or heterodimeric . [ 1 ]