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The therapeutic index varies widely among substances, even within a related group. For instance, the opioid painkiller remifentanil is very forgiving, offering a therapeutic index of 33,000:1, while Diazepam, a benzodiazepine sedative-hypnotic and skeletal muscle relaxant, has a less forgiving therapeutic index of 100:1. [9]
While relying on a graph for estimation is more convenient, this typical method yields less accurate and precise results. [6] The response or effect, E, is dependent on both the binding of the drug and the drug-bound receptor. The agonist that binds to the receptor and initiates the response is usually abbreviated A or D. At low agonist ...
Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic index. For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug ...
Population pharmacokinetics seeks to identify the measurable pathophysiologic factors and explain sources of variability that cause changes in the dose-concentration relationship and the extent of these changes so that, if such changes are associated with clinically relevant and significant shifts in exposures that impact the therapeutic index ...
A dose–response curve is a coordinate graph relating the magnitude of a dose (stimulus) to the response of a biological system. A number of effects (or endpoints) can be studied. The applied dose is generally plotted on the X axis and the response is plotted on the Y axis.
Cigna stock popped on Monday, rising as much as 16%, following a report from the Wall Street Journal that said the company had abandoned efforts to merge with rival Humana while announcing plans ...
The name comes from the idea that on a graph of concentration versus time, the line forms a U-shaped trough at the lowest region, before a new dose sends it higher again. The usual criterion is concentration in the blood serum , although in some instances local concentration within tissues is relevant.
The E. C. “Pete” Aldridge, Jr. Stock Index From January 2008 to April 2011, if you bought shares in companies when E. C. “Pete” Aldridge, Jr. joined the board, and sold them when he left, you would have a -25.3 percent return on your investment, compared to a -7.3 percent return from the S&P 500.