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  2. Lipid-based nanoparticle - Wikipedia

    en.wikipedia.org/wiki/Lipid-based_nanoparticle

    Development of solid lipid nanoparticles is one of the emerging fields of lipid nanotechnology (for a review on lipid nanotechnology, see [17]) with several potential applications in drug delivery, clinical medicine and research, as well as in other disciplines. Due to their unique size-dependent properties, lipid nanoparticles can possibly ...

  3. Selective organ targeting - Wikipedia

    en.wikipedia.org/wiki/Selective_organ_targeting

    Selective organ targeting (SORT) is a novel approach in the field of targeted drug delivery that systematically engineers multiple classes of lipid nanoparticles (LNPs) to enable targeted delivery of therapeutics to specific organs in the body.

  4. RNAi nanoparticles to target cancer - Wikipedia

    en.wikipedia.org/wiki/RNAi_nanoparticles_to...

    These four major types of nanoparticles are all nonionic lipids. Nonionic lipids are safe, nontoxic and biocompatible. Nanoplexes involve the nucleic acid (RNAi) being associated with the particle or encapsulated by it. Polyplexes are core-shell type nanoparticles. Lipoplexes are liposome structures characterized by a bilayer lipid membrane.

  5. Nanoparticle drug delivery - Wikipedia

    en.wikipedia.org/wiki/Nanoparticle_drug_delivery

    It can be directed to the location of cancer cells with sustained release behavior. Studies have also been done on gold nanoparticle responses to local near-infrared (NIR) light as a stimuli for drug release. In one study, gold nanoparticles functionalized with double-stranded DNA encapsulated with drug molecules, were irradiated with NIR light.

  6. Targeted drug delivery - Wikipedia

    en.wikipedia.org/wiki/Targeted_drug_delivery

    When the blood vessels form so rapidly, large fenestrae result that are 100 to 600 nanometers in size, which allows enhanced nanoparticle entry. Further, the poor lymphatic drainage means that the large influx of nanoparticles are rarely leaving, thus, the tumor retains more nanoparticles for successful treatment to take place. [8]

  7. Response evaluation criteria in solid tumors - Wikipedia

    en.wikipedia.org/wiki/Response_Evaluation...

    The criteria were published in February 2000 by an international collaboration including the European Organisation for Research and Treatment of Cancer , National Cancer Institute of the United States, and the National Cancer Institute of Canada Clinical Trials Group.

  8. Pieter Cullis - Wikipedia

    en.wikipedia.org/wiki/Pieter_Cullis

    Pieter Rutter Cullis FRS FRSC OBC OC is a Canadian physicist and biochemist known for his contributions to the field of lipid nanoparticles (LNP). [1] Cullis and co-workers have been responsible for fundamental advances in the development of nanomedicines employing lipid nanoparticle (LNP) technology for cancer therapies, gene therapies and vaccines.

  9. Nanomedicine - Wikipedia

    en.wikipedia.org/wiki/Nanomedicine

    Solid lipid nanoparticles represent a novel delivery system for some vaccines against SARS-CoV-2 (the virus that causes COVID-19). [60] In recent decades, nanosized adjuvants have been widely used to enhance immune responses to targeted vaccine antigens.

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