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Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors. Monogenetic obesity mostly affects the hypothalamus and leptin–melanocortin system (see hypothalamic obesity ...
Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
Syndromic obesity (SO) refers to obesity when it occurs as part of a syndrome, often along with intellectual disability. Often syndromic obesity is mediated by abnormal development of the hypothalamus (see hypothalamic obesity). Known types of syndromic obesity include some types of monogenic obesity and: [1] [2] Prader Willi syndrome; Bardet ...
Conversely, damage to this receptor has been shown to result in morbid obesity, and is the most commonly known cause of monogenic morbid obesity. [22] Mutation in an allele of the melanocortin-4 receptor causes 2-3% of childhood and adult obesity.
Along with neonatal diabetes, MODY is a form of the conditions known as monogenic diabetes. While the more common types of diabetes (especially type 1 and type 2) involve more complex combinations of causes involving multiple genes and environmental factors, each forms of MODY are caused by changes to a single gene (monogenic). [2]
Published in JAMA Health Forum on Friday, the study, "Changes in Adult Obesity Trends in the US," found that between 2022 and 2023, obesity in American adults between ages 26-75 dropped about 0.15%.
What causes childhood obesity? A variety of factors and situations can influence a child’s weight, such as genetics, nutrition, physical activity, a family’s access to affordable nutritious ...
Dina Peralta-Reich, MD, is an obesity medicine specialist and founder of New York Weight Wellness Medicine. Tina Tang , CPT, is a certified personal trainer, strength coach, and founder of Iron ...