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Doses of oral polio vaccine are added to sugar cubes for use in a 1967 vaccination campaign in Bonn, West Germany. During the race to develop an oral polio vaccine, several large-scale human trials were undertaken. By 1958, the National Institutes of Health had determined that OPV produced using the Sabin strains was the safest. [43]
Poliomyelitis (/ ˌ p oʊ l i oʊ ˌ m aɪ ə ˈ l aɪ t ɪ s / POH-lee-oh-MY-ə-LY-tiss), commonly shortened to polio, is an infectious disease caused by the poliovirus. [1] Approximately 75% of cases are asymptomatic; [5] mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia.
Polio: An American Story by David M. Oshinsky, professor of history at the University of Texas at Austin, documents the polio epidemic in the United States during the 1940s and 1950s and the race to develop a vaccine, which led to 2 different types of polio vaccine: inactivated poliovirus vaccine, developed by a team led by Jonas Salk, and oral poliovirus vaccine, developed by a team led by ...
The history of polio (poliomyelitis) infections began during prehistory. Although major polio epidemics were unknown before the 20th century, [1] the disease has caused paralysis and death for much of human history. Over millennia, polio survived quietly as an endemic pathogen until the 1900s when major epidemics began to occur in Europe. [1]
There are two kinds of polio vaccine—oral polio vaccine (OPV), which uses weakened poliovirus, and inactivated polio vaccine (IPV), which is injected. OPV is less expensive and easier to administer, and can spread immunity beyond the person vaccinated, creating contact immunity. It has been the predominant vaccine used.
Albert Sabin, a virologist who publicly disagreed with Salk and his killed vaccine, worked on creating a vaccine with live attenuated vaccines. [5] In January 1956, despite Cold War tensions, Mikhail Chumakov, the director of Moscow's Polio Research Institute, along with his wife virologist Marina Voroshilova, and his colleague Anatoli Smorodentsev, traveled to the U.S. in order to study the ...
There are some purported side effects that happen so rarely it is not proven that they are caused by the vaccine, they include deafness; long-term seizures, coma or lowered consciousness; permanent brain damage; Some side effects of the MMRV vaccine are [2] fever (1 in 6) mild rash (1 in 20) swelling of glands in cheeks or neck (1 in 75)
According to the U.S. Centers for Disease Control and Prevention, while "any vaccine can cause side effects", [11] most side effects are minor, primarily including sore arms or a mild fever. [11] Unlike most medical interventions vaccines are given to healthy people, where the risk of side effects is not as easily outweighed by the benefit of ...