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Legionella pneumophila, the primary causative agent for Legionnaire's disease, is an aerobic, pleomorphic, flagellated, non-spore-forming, Gram-negative bacterium. [1] [2] L. pneumophila is a intracellular parasite that preferentially infects soil amoebae and freshwater protozoa for replication.
The fatality rate of Legionnaires' disease has ranged from 5–30% during various outbreaks and approaches 50% for nosocomial infections, especially when treatment with antibiotics is delayed. [38] Hospital-acquired Legionella pneumonia has a fatality rate of 28%, and the principal source of infection in such cases is the drinking-water ...
Miocamycin is a macrolide antibiotic. [1] It has a spectrum activity similar to that of Erythromycin, but shows higher antimicrobial effect against certain bacteria including Legionella pneumophila (the causative agent of Legionnaires' Disease), Mycoplasma hominis, and Ureaplasma urealyticum. [1]
The legionella bacteria responsible for the disease lives and multiplies in water areas like hot tubs, air conditioners, mist sprayers in grocery store produce departments, and water systems.
Quinolones can enter cells easily and therefore are often used to treat intracellular pathogens such as Legionella pneumophila and Mycoplasma pneumoniae. For many gram-negative bacteria DNA gyrase is the target, whereas topoisomerase IV is the target for many gram-positive bacteria. Eukaryotic cells do not contain DNA gyrase or topoisomerase IV.
Walking pneumonia is most often caused by mycoplasma pneumoniae bacteria, while pneumonia can be caused by bacteria like streptococcus pneumoniae, hemophilus influenzae, Legionella pneumophila, or ...
Legionella is a genus of gram-negative bacteria that can be seen using a silver stain or grown in a special media that contains cysteine, an amino acid.It is known to cause legionellosis [3] (all illnesses caused by Legionella) including a pneumonia-type illness called Legionnaires' disease and a mild flu-like illness called Pontiac fever. [3]
Fluoroquinolones can enter in cells easily via porins, so are often used to treat intracellular pathogens such as Legionella pneumophila and Mycoplasma pneumoniae. For many Gram-negative bacteria, DNA gyrase is the target, whereas topoisomerase IV is the target for many Gram-positive bacteria. [citation needed]
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