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Peptic ulcer disease is when the inner part of the stomach's gastric mucosa (lining of the stomach), the first part of the small intestine, or sometimes the lower esophagus, gets damaged. An ulcer in the stomach is called a gastric ulcer , while one in the first part of the intestines is a duodenal ulcer . [ 1 ]
English: Age-standardised disability-adjusted life year (DALY) rates from Peptic ulcer disease by country (per 100,000 inhabitants). no data . less than 20 . 20-40 .
Eradication of H. pylori is recommended to treat the infection, including when advanced to peptic ulcer disease. The recommendations for first-line treatment is a quadruple therapy consisting of a proton-pump inhibitor , amoxicillin , clarithromycin , and metronidazole .
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A person with peptic ulcer disease experiences open sores on the lining of the stomach or small intestine.
A peptic ulcer is a defect that occurs in the first part of the small intestine or in the lining of the stomach. Gastric ulcers occur in the stomach whereas duodenal ulcers occur in the intestine. Small ulcers may not be noticeable, whereas large ulcers are painful and are considered medical emergencies.
Acid peptic diseases, such as peptic ulcers, Zollinger-Ellison syndrome, and gastroesophageal reflux disease, are caused by distinct but overlapping pathogenic mechanisms involving acid effects on mucosal defense. Acid reflux damages the esophageal mucosa and may also cause laryngeal tissue injury, leading to the development of pulmonary ...
In people with a confirmed peptic ulcer, proton pump inhibitors do not reduce death rates, later bleeding events, or need for surgery. [18] They may decrease signs of bleeding at endoscopy however. [18] In those with less severe disease and where endoscopy is rapidly available, they are of less immediate clinical importance. [16]