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Phenylephrine, sold under the brand names Neosynephrine and Sudafed PE among others, is a medication used as a decongestant for uncomplicated nasal congestion in the form of a nasal spray or oral tablet, [5] to dilate the pupil, to increase blood pressure given intravenously in cases of low blood pressure, and to relieve hemorrhoids as a suppository.
Phenylephrine has been sold for more than 75 years, predating the agency’s own regulations on drug effectiveness. “It is the FDA’s role to ensure that drugs are safe and effective,” Dr. ...
Phenylephrine is the main ingredient used in many common over-the-counter congestion products. It is safe to use, but an independent advisory committee to the FDA agreed Tuesday that it is ...
Do over-the-counter decongestants like Sudafed PE work? Doctors have said oral phenylephrine is ineffective to relieve nasal congestion. An FDA panel will reevaluate the evidence.
[13] [2] Phenylephrine has replaced pseudoephedrine in many over-the-counter oral decongestant products. [2] However, oral phenylephrine appears to be ineffective as a decongestant. [ 31 ] [ 32 ] In 2022, the combination with brompheniramine and dextromethorphan was the 265th most commonly prescribed medication in the United States, with more ...
Common decongestants include pseudoephedrine and phenylephrine. [14] Pseudoephedrine is an alpha-adrenergic receptor agonist that enacts a vasoconstrictive effect to reduce airflow resistance in the nasal cavity and allow easier breathing by relieving a stuffy or congested nose.
Big pharmaceutical companies like Johnson & Johnson may have to pull products from shelves
Phenylephrine (10 mg/30 mL) (nasal decongestant) Alcohol (10% by volume) The LiquiCap capsule version has the following active ingredients per pill, half the recommended adult dose: Acetaminophen (325 mg/pill) (pain reliever/fever reducer) Dextromethorphan (15 mg/pill) (cough suppressant) Doxylamine succinate (6.25 mg/pill) (antihistamine/hypnotic)