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Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug , [8] used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. [9] Bottle of Leflunomide (Arava) and tablet
RS3PE typically involves the joints of the extremities, specifically the metacarpophalangeal and proximal interphalangeal joints, wrists, shoulders, elbows, knees and ankles. [4] It is more common in older adults, with the mean age between 70 and 80 years in most studies. [4] [5] It occurs more often in men than in women with a 2:1 ratio.
The condition is commonly associated with vascular and cardiac changes associated with aging but can be caused by many other conditions, including congestive heart failure, kidney failure, liver cirrhosis, portal hypertension, trauma, alcoholism, altitude sickness, pregnancy, hypertension, sickle cell anemia, a compromised lymphatic system or merely long periods of time sitting or standing ...
The doctor can look for potential underlying causes, including dementia, medication effects, or environmental factors, Elhelou says. From there, they can suggest effective ways to help you manage ...
Inflammatory arthritis can sometimes cause symptoms in parts of the body other than the joints, like the eyes, heart, or lungs. As arthritis progresses, joint damage can get worse.
It is essential older people wear appropriate footwear to reduce their fall risk. Footwear should fit properly and have non-skid, or non-slip, soles. This includes shoes and sneakers, but also ...
In the arms and legs, the fluid accumulates in the tissues, causing swelling. This is most prominent in the legs due to the effects of gravity. Conditions that predispose to increased hydrostatic pressure (heart failure and renal insufficiency) or decreased oncotic pressure (liver failure, malnutrition, nephrotic syndrome) places individuals at ...
Allergies – Allergic reactions can lead to leaks in the subcutaneous capillary beds which can cause swelling in the face, including around the eyes. [citation needed] Skin disorders – Eye puffiness can be a side effect of certain skin disorders, such as dermatitis, if the affected area becomes very sensitive, leading to swelling. [citation ...
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