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Statins remain a first-line treatment in familial hypercholesterolemia, [53] although other cholesterol-reducing measures may be required. [55] In people with homozygous deficiencies, statins may still prove helpful, albeit at high doses and in combination with other cholesterol-reducing medications. [56]
Statins are a competitive antagonists of HMG CoA, as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). [5] By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway.
Statins with shorter half-lives are more effective when taken in the evening, so their peak effect occurs when the body’s natural cholesterol production is at its highest. A recent meta-analysis suggested that statins with longer half-lives, including atorvastatin, may also be more effective at lowering LDL cholesterol if taken in the evening ...
The makers of statins may want to ramp up production as new guidelines by the American College of Cardiology and the American Heart Association promote the effectiveness of these drugs in managing ...
Statins are medications that can lower cholesterol by reducing the body's production of the substance. They can also help reduce triglycerides and raise HDL cholesterol. They can also help reduce ...
Statins are medications that can lower cholesterol by reducing the body's production of the substance. They can also help reduce triglycerides and raise HDL cholesterol. There are many different ...
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