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  2. Acamprosate - Wikipedia

    en.wikipedia.org/wiki/Acamprosate

    Acamprosate, sold under the brand name Campral, is a medication which reduces alcoholism cravings. [ 1 ] [ 5 ] It is thought to stabilize chemical signaling in the brain that would otherwise be disrupted by alcohol withdrawal . [ 6 ]

  3. Kindling (sedative–hypnotic withdrawal) - Wikipedia

    en.wikipedia.org/wiki/Kindling_(sedative...

    Ethanol (alcohol) has a very similar mechanism of tolerance and withdrawal to benzodiazepines, involving the GABA A receptors, NMDA receptors and AMPA receptors, but the majority of research into kindling has primarily focused on alcohol. [6] An intensification of anxiety and other psychological symptoms of alcohol withdrawal also occurs. [10]

  4. Alcohol (drug) - Wikipedia

    en.wikipedia.org/wiki/Alcohol_(drug)

    Alcohol causes generalized CNS depression, is a positive allosteric GABA A ... Alcoholism or its medical diagnosis alcohol use disorder refers to alcohol addiction, ...

  5. Alcohol withdrawal syndrome - Wikipedia

    en.wikipedia.org/wiki/Alcohol_withdrawal_syndrome

    Alcohol depresses the central nervous system, slowing cerebral messaging and altering the way signals are sent and received. Progressively larger amounts of alcohol are needed to achieve the same physical and emotional results. The drinker eventually must consume alcohol just to avoid the physical cravings and withdrawal symptoms.

  6. Delirium tremens - Wikipedia

    en.wikipedia.org/wiki/Delirium_tremens

    Delirium tremens is a component of alcohol withdrawal hypothesized to be the result of compensatory changes in response to chronic heavy alcohol use. Alcohol positively allosterically modulates the binding of GABA , enhancing its effect and resulting in inhibition of neurons projecting into the nucleus accumbens , as well as inhibiting NMDA ...

  7. Effects of alcohol on memory - Wikipedia

    en.wikipedia.org/wiki/Effects_of_alcohol_on_memory

    Alcohol acts as a general central nervous system depressant, but it also affects some specific areas of the brain to a greater extent than others. Memory impairment caused by alcohol has been linked to the disruption of hippocampal function—particularly affecting gamma-Aminobutyric acid (GABA) and N-methyl-D-aspartate (NMDA) neurotransmission which negatively impacts long-term potentiation ...

  8. Gabapentin - Wikipedia

    en.wikipedia.org/wiki/Gabapentin

    When taken in excess, gabapentin can induce euphoria, a sense of calm, a cannabis-like high, improved sociability, and reduced alcohol or cocaine cravings. [ 159 ] [ 160 ] [ 161 ] Also known on the streets as "Gabbies", [ 162 ] gabapentin was reported in 2017 to be increasingly abused and misused for these euphoric effects.

  9. Alcohol abuse - Wikipedia

    en.wikipedia.org/wiki/Alcohol_abuse

    It modulates GABA neurotransmission, and inhibits glutamate receptors, reducing cravings for alcohol and alcohol use. [ 82 ] Gabapentin : Gabapentin is an anticonvulsant approved for the management of epileptic seizures and neuropathic pain and used off label in the treatment of alcohol use disorder.

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