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Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa).
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
The mammalian target of rapamycin (mTOR), [5] also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. [6] [7] [8] mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein ...
Rapamycin was found to have anti-fungal, immunosuppressive and anti-tumor capabilities. Currently, rapamycin is an FDA approved “on label” prescription drug for treating certain types of ...
Rapamycin slows the ovaries down, so they release less than the usual amount of eggs a month. (But, again, this study is ongoing.) ... and that scientists still have a long way to go before they ...
Erythromycin.The macrolide ring is the lactone (cyclic ester) at upper left. Clarithromycin Roxithromycin. Macrolides are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached.
Additionally, there is a small component of the project that explores the use of pharmaceuticals to potentially increase life span of dogs. The project has implications for improving the life spans of humans and is an example of geroscience. [3] [4] Chemical structure of rapamycin, a pharmaceutical under evaluation for its effects on longevity
CDs differ from savings accounts in that you risk a withdrawal penalty if you need to access your money before the CD matures — though a short-term CD ladder can help you leverage today's ...
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