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Meconium aspiration syndrome (MAS), also known as neonatal aspiration of meconium, is a medical condition affecting newborn infants. It describes the spectrum of disorders and pathophysiology of newborns born in meconium-stained amniotic fluid (MSAF) and have meconium within their lungs.
The syndrome develops in about 20% of human pregnancies continuing past the expected delivery date. [3] Features of post-maturity syndrome include oligohydramnios (a deficiency of amniotic fluid); [4] meconium aspiration (breathing meconium in the amniotic fluid); and macrosomia (being overly large).
The presence of meconium within the lungs, known as meconium aspiration syndrome, can obstruct the airways and also deactivate the newborn's surfactant. The inflammation that also results from the inhalation of meconium also causes airway constriction, resulting in poor ventilation of the alveoli and inadequate oxygenation of the pulmonary ...
Bartlett reported the first neonatal survivor of ECMO, referred to as Baby Esperanza, in 1976. Baby Esperanza suffered lung damage from meconium aspiration syndrome and she was so sick that ECMO was applied as a last-ditch effort to save her life. The baby spent three days on Bartlett's machine and she recovered.
Causes include hypoxia, meconium aspiration, and respiratory distress syndrome. Left untreated, this can lead to hypoxic respiratory failure (HRF). [1] Decreased diameter of pulmonary vessels with hypertrophy of vessel walls: This has a poor prognosis, as it is a fixed abnormality.
Neonatal withdrawal or neonatal abstinence syndrome (NAS) ... meconium, and umbilical cord tissue. [29] Although these tests are recommended per guidelines, there are ...
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07-30-1996 Treatment of meconium aspiration syndrome in newborn infants; 07-17-1995 Treatment of acute respiratory distress syndrome in adults. 05-23-2006 Prevention of bronchopulmonary dysplasia in premature infants; 10-21-2005 Treatment of bronchopulmonary dysplasia in premature infants.