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OpenBiome is a nonprofit health research organization based in Massachusetts accelerating research on the human microbiome. They partner with leading researchers, clinicians and innovators to advance and ensure access to novel and affordable microbiome therapeutics.
Venn diagram showing pharmacomicrobiomics as a sub-field of genomics, microbiology, and pharmacology. Pharmacomicrobiomics, proposed by Prof. Marco Candela for the ERC-2009-StG project call (proposal n. 242860, titled "PharmacoMICROBIOMICS, study of the microbiome determinants of the different drug responses between individuals"), and publicly coined for the first time in 2010 by Rizkallah et ...
Design of engineered live bacterial therapeutics [1]. Bacterial therapy is the therapeutic use of bacteria to treat diseases.Bacterial therapeutics are living medicines, and may be wild type bacteria (often in the form of probiotics) or bacteria that have been genetically engineered to possess therapeutic properties that is injected into a patient.
In 2012, Berry founded Seres Therapeutics, which pioneered microbiome therapeutics. [6] The company raised over $130M as a private company, including a $65M investment from Nestle Health Sciences. [7] Seres publicly listed on the Nasdaq under the symbol MCRB in June 2015, raising $134M. [8]
He served as chief technology officer at Seres when the company developed SER-109, one of the first microbiome therapeutics. [14] In 2018, von Maltzahn cofounded two biotechnology startups, Generate Biomedicines [15] and Tessera Therapeutics. [16] Two years later he became a general partner at Flagship. [17]
The microbiome is defined as a characteristic microbial community occupying a reasonable well-defined habitat which has distinct physio-chemical properties. The microbiome not only refers to the microorganisms involved but also encompass their theatre of activity, which results in the formation of specific ecological niches.
Depiction of prevalences of various classes of bacteria at selected sites on human skin. Prior to the HMP launch, it was often reported in popular media and scientific literature that there are about 10 times as many microbial cells and 100 times as many microbial genes in the human body as there are human cells; this figure was based on estimates that the human microbiome includes around 100 ...
The human microbiome is the aggregate of all microbiota that reside on or within human tissues and biofluids along with the corresponding anatomical sites in which they reside, [1] [2] including the gastrointestinal tract, skin, mammary glands, seminal fluid, uterus, ovarian follicles, lung, saliva, oral mucosa, conjunctiva, and the biliary tract.